When Simon and his new girlfriend Rose (guest-star Sarah Thompson), make an unexpected visit to Glenoak to meet their respective parents, Annie begins to suspect their relationship might be on…

After discovering that Mary (Jessica Biel, who does not appear in the episode) has filed for divorce and signed away custody of her son, Matt is at a loss for…

Kevin learns that Simon has been kicked out of his dorm for allowing a school friend, Christina (guest-star Lauren Storm), to stay with him. When Eric comes to the rescue,…

Lindsay presses Richard Bay to explain a questionable arrest of her client, who is an illegal alien. She ultimately discovers that the police planted drugs on her client, in order…

While trying to work out the ramifications of his new alliance with Renard, Nick investigates a murder where the victim was blinded with parasites sprayed into her eyes. Meanwhile, Juliette’s…

When a 16-year-old girl who had received a kidney transplant from her father arrives at the emergency room feeling dizzy, Carter traces the problem to a new drug that the…

As preparations continue for Meredith and Derek’s wedding, Izzie receives a surprise hospital visit from her handful-of-a-mother, Robbie. Meanwhile, a newly sober Thatcher visits his daughters, Meredith and Lexie, in…

Don’s father-in-law pays a visit to his daughter’s family. Peggy works hard on a campaign while the firm tries to decide if they will accommodate an unusual request from a…

Don and his father-in-law cross paths. Meanwhile, Peggy is in search of a new roommate; and a rich new client is excited to be doing business with the firm.

Betty visits her father; Paul’s girlfriend tries to convince him to prioritize his duties; Pete’s mother disapproves of his and Trudy’s idea.